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5. Imperial College of Science, Technology and Medicine, London:
The group at the Kennedy Institute of Rheumatology have considerable experience in the analysis of mechanisms involved in both human rheumatoid arthritis and mouse collagen-induced arthritis, and have been working on the role of angiogenesis in rheumatoid arthritis and the use of adenoviruses for gene therapy of collagen-induced arthritis. There is several years' experience with the techniques used for the analysis of angiogenesis and difficult techniques of synovial dissection in the mouse. The techniques used for the analysis of angiogenesis are the same as those used to discover the successful use of anti-TNF antibody in rheumatoid arthritis. The main role of this lab will be (1) analyzing the role of angiogenesis inhibition in arthritis together with collaborating participants, (2) investigating mechanism of action of angiogenesis inhibition (3) developing new therapeutic agents, using antibodies or adenovirus and testing them in vitro or animal models. All facilities for this work are available. There is a modern animal house equipped with isolators for the mice injected with adenovirus, as well as facilities for image analysis of joint tissue by histology and immunohistochemistry.
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