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7. Redoxis AB, (Biovitrum AB, Arexis AB), Gothenburg
1. Vingsbo-Lundberg C., Nordquist N., Olofsson P., Sundvall M., Saxne T., Pettersson U., and Holmdahl R. (1998). Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats. Nat Genet 20:401-4.
2. Identification and isolation of dominant susceptibility loci for pristane-induced arthritis. Olofsson P, Holmberg J, Pettersson U, Holmdahl R. J Immunol. 2003 Jul 1;171(1):407-16.
3. Olofsson P., Holmberg J., Tordsson J., Lu S., Akerstrom B., and Holmdahl R. (2003). Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Nat Genet 33: 25-32.
4. Hultqvist M., Olofsson P., Holmberg J., Backstrom B. T., Tordsson J., and Holmdahl R. (2004). Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc Natl Acad Sci U S A 101: 12646-51.
5. A new therapy of arthritis in rats using oxidative burst inducers. Malin Hultqvist, Peter Olofsson, Kyra Gelderman, Jens Holmberg, Shemin Lu and Rikard Holmdahl. PLoS Med. 2006 Sep 12;3(9).
8 University of Applied Sciences Bonn-Rhein-Sieg
1. Hoefer MM, Boneberg EM, Grotegut S, Kusch J, Illges H: Possible tetramerisation of the proteasome maturation factor POMP/proteassemblin/hUmp1 and its subcellular localisation. Int J Biol Macromol 2006, 38(3-5):259-267.
2. Grottenthaler T, Kempis J, Goldacker S, Illges H: Soluble CD21 in sera and synovial fluid of arthritic patients. Rheumatol Int 2006, 26(3):240-243.
3. Aichem A, Masilamani M, Illges H: Redox regulation of CD21 shedding involves signaling via PKC and indicates the formation of a juxtamembrane stalk. J Cell Sci 2006, 119(Pt 14):2892-2902.
4. Spohn G, Schwarz K, Maurer P, Illges H, Rajasekaran N, Choi Y, Jennings GT, Bachmann MF: Protection against osteoporosis by active immunization with TRANCE/RANKL displayed on virus-like particles. J Immunol 2005, 175(9):6211-6218.
5. Solomon S, Rajasekaran N, Jeisy-Walder E, Snapper SB, Illges H: A crucial role for macrophages in the pathology of K/B x N serum-induced arthritis. Eur J Immunol 2005, 35(10):3064-3073.
6. Solomon S, Kassahn D, Illges H: The role of the complement and the FcgammaR system in the pathogenesis of arthritis. Arthritis Res Ther 2005, 7(4):129-135.
7. Moller S, Mix E, Bluggel M, Serrano-Fernandez P, Koczan D, Kotsikoris V, Kunz M, Watson M, Pahnke J, Illges H et al: Collection of soluble variants of membrane proteins for transcriptomics and proteomics. In Silico Biol 2005, 5(3):295-311.
8. Hu HG, Illges H, Gruss C, Knippers R: Distribution of the chromatin protein DEK distinguishes active and inactive CD21/CR2 gene in pre- and mature B lymphocytes. Int Immunol 2005, 17(6):789-796.
9. Boneberg EM, von Seydlitz E, Propster K, Watzl H, Rockstroh B, Illges H: D3 dopamine receptor mRNA is elevated in T cells of schizophrenic patients whereas D4 dopamine receptor mRNA is reduced in CD4(+)-T cells. J Neuroimmunol 2005.
9.Center of Rheumatology and WHO Collaborating Center, Zurich
Peer reviewed papers:
1. Wieser C, Stumpf D, Grillhösl C, Lenenfelder D, Gay S, Fleckenstein B, Ensser A. Regulated and constitutive expression of anti-inflammatory cytokines by nontransforming herpesvirus saimiri vectors. Gene Therapy, 12:395-406, 2005, IF: 4.836
2. Hermann F, Forster A, Chenevard R, Enseleit F, Hürlimann D, Corti R, Spieker LE, Frei D, Hermann M, Riesen W, Neidhart M, Michel BA, Hellermann JP, Gay RE, Lüscher TF, Gay S, Noll G, Ruschitzka F. Simvastin improves endothelial function in patients with rheumatoid arthritis. J Am Coll Card 45:461-464, 2005, IF:9.200
3. Distler JH, Jüngel A, Huber LC, Seemayer CA, Reich CF 3rd, Gay RE, Michel BA, Fontana A, Gay S, Pisetsky DS, Distler O. The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles. Proc Natl Acad Sci USA, 102:2892-2897, 2005, IF: 10.231
4. Del Rosso A, Distler O, Milia AF, Emanueli C, Ibba-Manneschi L, Guiducci S, Conforti ML, Generini S, Pignone A, Gay S, Madeddu P, Matucci-Cerinic M. Increased circulating levels of tissue kallikrein in systemic sclerosis correlate with microvascular involvement. Ann Rheum Dis 64:382-387, 2005, IF: 6.956
5. Distler JH, Jüngel A, Kowal-Bielecka O, Michel BA, Gay RE, Sprott H, Matucci-Cerinic M, Chilla M, Reich K, Kalden JR, Muller-Ladner U, Lorenz HM, Gay S, Distler O. Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis. Arthritis Rheum 52:856-864, 2005, IF: 7.421
6. Maier W, Altwegg LA, Corti R, Gay S, Hersberger M, Maly FE, Sutsch G, Roffi M, Neidhart M, Eberli FR, Tanner FC, Gobbi S, von Eckardstein A, Luscher TF. Inflammatory markers at the site of ruptured plaque in acute myocardial infarction: locally increased interleukin-6 and serum amyloid a but decreased C-reactive protein. Circulation 22:1355-1361, 2005, IF: 11.632
7. Shen H, Aeschlimann A, Reisch N, Gay RE, Simmen BR, Michel BA, Gay, S, Sprott, H. Kappa and delta opioid receptors are expressed but down-regulated in fibroblast like synoviocytes of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum 52: 1402-1410, 2005, IF: 7.421
8. Rutkauskaite E, Volkmer D, Shigeyama Y, Schedel J, Pap G, Muller-Ladner U, Meinecke I, Alexander D, Gay RE, Drynda S, Neumann W, Michel BA, Aicher WK, Gay S, Pap T. Retroviral gene transfer of an antisense construct against membrane type 1 matrix metalloproteinase reduces the invasiveness of rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 52:2010-2014, 2005, IF:7.421
9. Steffel J, Hermann M, Greutert H, Gay S, Luscher TF, Ruschitzka F, Tanner FC. Celecoxib decreases endothelial tissue factor expression through inhibition of c-Jun terminal NH2 kinase phosphorylation: Circulation 111:1685-9, 2005, IF: 11.632
10. Kowal-Bielecka O, Kowal K, Distler O, Rojewska J, Bodzenta-Lukaszyk A, Gay RE, Gay S, Sierakowski S. Cyclooxygenase and lipoxygenase-derived eicosanoids in bronchoalveolar lavage fluid from patients with scleroderma lung disease: An imbalance between pro- and anti-inflammatory lipid mediators. Arthritis Rheum 52:3783-91, 2005, IF: 7.421
11. Distler JHW, Huber LC, Hueber AJ, Reich CF, Gay S, Distler O, Pisetsky DS. The release of microparticles by apoptotic cells and their effects on macrophages. Apoptosis 10:731-741, 2005, IF: 4.497
12. Neidhart M, Zaucke F. von Knoch R, Jungel A, Michel BA, Gay RE, Gay S. Galectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein. Ann Rheum Dis 64:419-424, 2005, IF:6.956
13. Brentano F, Schorr O, Gay RE, Gay S, Kyburz D. RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3. Arthritis Rheum 52: 2656-2665, 2005, IF: 7.421
14. Neidhart M, Jungel A, Ospelt C, Michel BA, Gay RE, Gay S. Deficient expression of interleukin-10 receptor alpha chain in rheumatoid arthritis synovium: Limitation of animal models of inflammation. Arthritis Rheum 52: 3315-3318, 2005, IF: 7.414
15. Sprott H, Shen H, Gay S, Aeschlimann A. Acetaminophen may act through ß endorphin. Ann Rheum Dis 64: 1522, 2005, IF: 6.956
16. Distler JH, Jungel A, Kurowska-Stolarska M, Michel BA, Gay RE, Gay S, Distler O. Nucleofection: a new, highly efficient transfection method for primary human keratinocytes. Exp Dermatol 14:315-20, 2005, IF: 2.095
17. Salemi S, Aeschlimann A, Reisch N, Jungel A, Gay RE, Heppner FL, Michel BA, Gay S, Sprott H. Detection of kappa and delta opioid receptors in skin-outside the nervous system. Biochem Biophys Res Commun 338:1012-1017, 2005, IF: 3.000
18. Distler JH, Jüngel A, Caretto D, Kowal-Bielecka O, Gay RE, Michel BA, Müller-Ladner U, Kalden JR, Gay S, Distler O. MCP-1 released from glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4 from T cells, Arthritis Rheum 54:214-225, 2006, IF:7.421
19. Ehling A, Schäffler A, Herfarth H, Grifka J, Distler O, Tarner IH, Distler JH, Gay S, Schölmerich J, Neumann E, Müller-Ladner U. The potential of adiponectin in driving arthritis, J Immunol 176:4468-4478, 2006, IF: 6.387
20. Shen H, Sprott H, Aeschlimann A, Gay RE, Michel BA, Gay S, Sprott H. Analgesic action of acetaminophen in symptomatic osteoarthritis of the knee. Rheumatology (Oxford). 45:765-770, 2006, IF: 4.226
21. Jüngel A, Baresova V, Ospelt C, Simmen BR, Michel BA, Gay RE, Gay S, Seemayer CA, Neidhart M. Trichostatin A sensitises rheumatoid arthritis synovial fibroblasts for TRAIL-induced apoptosis. Ann Rheum Dis. 65:910-912, 2006, IF: 6.956
22. Kurowska-Stolarska M, Distler J, Rudnicka W, Neumann E, Pap T, Wenger R, Jüngel A, Michel BA, Müller-Ladner U, Gay RE, Maslinski W, Gay S and Distler O. Expression of the inhibitor of differentiation-2 (Id-2) in synovial fibroblasts promotes osteoclastogenesis in rheumatoid arthritis, submitted
23. Huber LA, Jüngel A, Distler JHW, Moritz F, Gay RE, Michel BA, Pisetsky DS, Gay S, Distler O. The role of membrane lipids in the induction of macrophage apoptosis by microparticles, Apoptosis, in press, 2006
24. Schulze-Horsel U, Distler O, Jüngel A, Huber LC, Simmen B, Gay S, Pisetsky DS, Kalden JR, Jörg H.W. Distler JHW. Microparticles stimulate the synthesis of prostaglandin E2 via trans-cellular lipid transport, submitted
25. Jaschko G, Hepp U, Berkhoff M, Schmet M, Michel BA, Gay S, Sprott H. Serum serotonin levels are not useful in diagnosing fibromyalgia. Ann Rheum Dis, in press, 2006
26. Distler JHW, Jüngel A, Huber LC, Schulze-Horsel U, Gay RE, Michel BA, Hauser T, Schett G, Gay S, Distler O. Imatinib mesylate decreases the production of extra cellular matrix and prevents the development of experimental dermal fibrosis. Arthritis Rheum, in press, 2006
Reviews, Editorials and published Lectures (2004-2006)
(participation of the PhD-Students highlighted)
1. Meinecke I, Rutkauskaite E, Gay S, Pap T. The role of synovial fibroblasts in mediating joint destruction in rheumatoid arthritis. Curr Pharm Des 11:563-568, 2005
2. Tarner IH, Harle P, Muller-Ladner U, Gay RE, Gay S. The different stages of synovitis: acute vs chronic, early vs late and non-erosive vs erosive. Best Pract Res Clin Rheumatol 19:19-35, 2005
3. Brentano F., Kyburz D, Schorr O, Gay R, Gay S. The role of Toll-like receptor signalling in the pathogenesis of arthritis. Cell Immunol 233:90-96, 2005
4. Wunder A, Straub RH, Gay S, Funk J, Muller-Ladner U. Molecular imaging: novel tools in visualizing rheumatoid arthritis. Rheumatology 44:1341-1349, 2005
5. Ospelt C, Neidhart M, Gay RE, Gay S. Gene analysis for exploring the effects of drugs in rheumatoid arthritis. Arthritis Rheum 52:2248-56, 2005
6. Neumann E, Gay S, Muller-Ladner U. The RANK/RANKL/osteoprotegerin system in rheumatoid arthritis: New insights from animal models. Arthritis Rheum 52: 2960-2967, 2005
7. Distler JH, Pisetsky DS, Huber LC, Kalden JR, Gay S, Distler O. Microparticles as regulators of inflammation: Novel players of cellular crosstalk in the rheumatic diseases. Arthritis Rheum 52:3337-3348, 2005
8. Pap T, Meinecke I, Muller-Ladner U, Gay S. Are fibroblasts involved in joint destruction? Ann Rheum Dis. 64: Suppl 4:iv52-54, 2005
9. Ospelt C, Gay S. Somatic mutations in mitochondria: the chicken or the egg? Arthritis Res Ther 7:179-80, 2005
10. Moritz F, Wagner U, Distler O, Seidel W, Gay S, Hantzschel H. [Cardiovascular manifestations in rheumatoid arthritis].Z Rheumatol 64:222-8, 2005
11. Muller-Ladner U, Pap T, Gay RE, Neidhart M, Gay S. Mechanisms of Disease: the molecular and cellular basis of joint destruction in rheumatoid arthritis. Nature Clinical Practise Rheumatology 1:102-110, 2005
12. Moritz F, Distler O, Ospelt C, Gay RE, Gay S. Gene transfer for designing novel treatments for rheumatoid arthritis. Nature Clinical Practise Rheumatology 2: 153-162, 2006
13. Pritzker KP, Gay S, Jimenez SA, Ostergaard K, Pelletier JP, Revell PA, Salter D, van den Berg WB. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage 1:13-29, 2006
14. Tarner IH, Neumann E, Gay S, Fathman CG, Muller-Ladner U. Developing the concept of adoptive cellular gene therapy of rheumatoid arthritis. Autoimmun Rev. 5(2):148-152, 2006
15. Senolt L, Grigorian M, Lukanidin E, Michel BA, Gay RE, Gay S, Pavelka K, Neidhart M. S100A4 (Mts1): Is there any relation to the pathogenesis of rheumatoid arthritis? Autoimmun Rev 5:129-31, 2006
16. Karouzakis E, Neidhart M, Gay RE, Gay S. Molecular and cellular basis of rheumatoid joint destruction. Immunol Lett. 2006 May 24; [Epub ahead of print]
17. Moritz F, Distler O, Gay RE, Gay S. [Molecular and cellular basis of joint destruction in rheumatoid arthritis.] Dtsch Med Wochenschr. 131:1546-1551, 2006
18. Luscher TF, Gay S, Ruschitzka FT. Introduction. J Cardiovasc Pharmacol. 47 Suppl 1:v-vi, 2006
19. Stanczyk J, Ospelt C, Gay RE, Gay S. Synovial cell activation. Curr Opin Rheumatol. 18:262-267, 2006
20. Huber LC, Distler O, Gay RE, Gay S. Antisense strategies in degenerative joint diseases: sense or nonsense? Adv Drug Deliv Rev. 58:285-299, 2006
21. Huber LC, Distler O, Tarner I, Gay RE, Gay S, Pap T. Synovial fibroblasts: key players in rheumatoid arthritis. Rheumatology (Oxford). 45:669-675, 2006
22. Hashimoto A, Tarner IH, Gay RE, Muller-Ladner U, Gay S, Neumann E. High-resolution molecular analysis for research in rheumatology. Curr Rheumatol Rep. 2006 8:1-2, 2006
23. Huber LC, Gay S, Distler O, Pisetsky DS. The effect of UVB on lupus skin: new light on the role of apoptosis in the pathogenesis of autoimmunity. Rheumatology (Oxford). 45:500-501, 2006
24. Tarner IH, Neumann E, Gay S, Fathman CG, Muller-Ladner U. Developing the concept of adoptive cellular gene therapy of rheumatoid arthritis. Autoimmun Rev. 5:148-152, 2006
25. Senolt L, Grigorian M, Lukanidin E, Michel BA, Gay RE, Gay S, Pavelka K, Neidhart M. S100A4 (Mts1): is there any relation to the pathogenesis of rheumatoid arthritis? Autoimmun Rev. 5:129-131, 2006.
ACR-Abstracts 2006
(participation of the PhD-Students highlighted)
1. Expression of TIMP-3 is regulated in synovial fibroblasts by genomic methylation. Emmanuel Karouzakis, Michel Neidhart, Christoph Kolin, Michel Beat, Renate E. Gay, Steffen Gay.
2. Histone deacetylase/ acetylase activity is reduced in rheumatoid arthritis synovial tissue. Lars C. Huber, Hossein Hemmatazad, Matthias Brock, Falk Moritz, Jörg H.W. Distler, Michelle Trenkmann, Renate E. Gay, Christoph Kolling, Beat A. Michel, Steffen Gay, Oliver Distler, Astrid Jüngel.
3. Immunohistochemical Localization of the Proto-Oncogene Product FBI-1 (zbtb7) in RA Synovium and Pannus. Frank Pessler, Steffen Gay, Pier-Paolo Pandolfi, H. Ralph Schumacher.
4. Expression and regulation of the mitochondrial antiviral signaling protein (MAVS) in rheumatoid arthritis. Caroline Ospelt, Michel Neidhart, Beat A. Michel, Beat R. Simmen, Renate E. Gay, Steffen Gay.
5. The SUMO-specific protease SENP-1 inhibits MMP expression in rheumatoid arthritis synovial fibroblasts (RASF). Hanna Maciejewska, Mariam Al-Shamisi, Renate E. Gay, Beat R. Simmen, Beat A. Michel, Michel Neidhart, Ingmar Meinecke, Thomas Pap, Steffen Gay, Astrid Jüngel.
6. The role of the adipocytokines resistin, adiponectin and of surfactant protein A as modulators of the proinflammatory response in RA. Anette Knedla, Stefanie Lefèvre, Andreas Kampmann, Jürgen Steinmeyer, Henning Stürz, Werner Seeger, Andreas Günther, Steffen Gay, Ulf Müller-Ladner, Elena Neumann.
7. Increased expression and proinflammatory activity of PBEF / visfatin in rheumatoid arthritis. Fabia Brentano, Olivier Schorr, Caroline Ospelt, Joanna Stanczyk, Beat R. Simmen, Renate E. Gay, Steffen Gay, Diego Kyburz.
8. Imatinib mesylate (Gleevec) inhibits efficiently the production of extracellular matrix proteins in dermal fibroblasts. Jörg H.W. Distler, Astrid Jüngel, Lars C. Huber, Steffen Gay, Beat A. Michel, Joachim R. Kalden, Oliver Distler.
9. Migration capability of RA synovial fibroblasts in the SCID mouse model for RA. Andreas Kampmann, Anette Knedla, Ingo H. Tarner, Henning Stürz, Jürgen Steinmeyer, Steffen Gay, Ulf Müller-Ladner, Elena Neumann.
10. Clinical and histopathological findings in patients with ankylosing spondylitis before and after surgical treatment for axis correction and erection of the spine. Jürgen Braun, Xenofon Baraliakos, Caren Zelder, Christian Seemeyer, Renate Gay, Heinrich Boehm, Steffen Gay, Michael Neidhart.
11. Tie2/Ang-1 at sites of invasion in rheumatoid arthritis (RA). Falk Moritz, Lars C. Huber, Jörg H.W. Distler, Astrid Jüngel, Beat R. Simmen, Beat A. Michel, Renate E. Gay, Steffen Gay, Oliver Distler.
12. Activation of ERK and SMAD2 kinases signal the TGF-beta induced and laminin-1 facilitated expression of MMP-3 in synovial fibroblasts. Maik Hoberg, Maximilian Rudert, Thomas Pap, Gerd Klein, Steffen Gay, Wilhelm K. Aicher.
13. CD4+ CD25high hegulatory T cells in systemic sclerosis (SSc). Falk Moritz, Lars C. Huber, Jörg H.W. Distler, Astrid Jüngel, Beat A. Michel, Renate E. Gay, Steffen Gay, Oliver Distler.
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