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1. University of Rostock:
1. Gierer P, Ibrahim S, Mittlmeier T, Koczan D, Moeller S, Landes J, Gradl G, Vollmar B. Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis. Arthritis Res Ther 2005;7: R868-876
2. Serrano-Fernandez P, Ibrahim SM, Koczan D, Zettl UK, Möller S. In silico fine-mapping: narrowing disease-associated loci by intergenomics. Bioinformatics 2005;21:1737-1738.
3. Bauer K, Knipper A, Mix E, Thiesen H-J, Holmdahl R, Ibrahim SM. Perforin Deficiency attenuates Collagen-Induced Arthritis. Arthritis Res Ther 2005;7:R877-884
4. Johannesson M, Olsson LM, Lindqvist A-KB, Möller S, Koczan D, Wester-Rosenlöf L, Thiesen H-J, Ibrahim S, Holmdahl R. Gene expression profiling of arthritis using a QTL chip reveals a complex gene regulation of the Cia5 region in mice. Genes and Immunity 2005;6:575-583.
5. X. Yu, K.Bauer, P. Wernhoff, D. Koczan, S. Möller, H-J Thiesen, and S. M. Ibrahim. Fine-mapping of collagen-induced arthritis quantitative trait loci in an advanced intercross line. J. Immunol. in Press
6. Xinhua Yu, Kristin Bauer, Dirk Koczan, Hans-Jürgen Thiesen and Saleh M. Ibrahim. Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen induced arthritis. In revision.
7. Xinhua Yu, Kristin Bauer, Patrik Wernhoff, and Saleh M. Identification of quantitative trait loci using an advanced intercross line. Submitted
8. T.C.T.M. van der Pouw Kraan, C.A. Wijbrandts, L.G. van Baarsen, A.E. Voskuyl, F. Rustenburg, J.M. Baggen, S.M. Ibrahim, M.Fero, B.A.C. Dijkmans, P.P. Tak, and C.L. Verweij. Rheumatoid Arthritis subtypes identified by genomic profiling of peripheral blood cells: Assignment of a type I interferon signature in a subpopulation of patients. Ann. Rheum. Dis. In press.
9. Yvonne Raatz, David Essex, Saleh Ibrahim and and Ewa Paleolog . Expression profiling of angiogenic markers in murine CIA models
Vascular Pharmacology, Volume 45, Issue 3, September 2006, Page e13
10. Sehnert B, Gierer P, Ibrahim S, Kuhl A, Voll R, Nandakumar KS, Holmdahl R, Hallmann R, Vollmar B, Burkhardt H. Modulation of granulocyte-endothelium interactions by antileukoproteinase: inhibition of anti-type II collagen antibody-induced leukocyte attachment to the synovial endothelium. Arthritis Res Ther. 2006 Jun 15;8(4):R95
2 Lund University
1. Hultqvist M, Olofsson P, Holmberg J, Bäckström BT, Tordsson J, Holmdahl R. Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc Natl Acad Sci U S A 101:12646-51, 2004.
2. Gelderman KA, Hultqvist M, Holmberg J, Olofsson P, Holmdahl R: T cell surface redox levels determine T cell reactivity and arthritis susceptibility. Proc Natl Acad Sci U S A; in press, 2006
3. Hultqvist M, Olofsson P, Gelderman KA, Holmberg J, Holmdahl R: A new arthritis therapy with oxidative burst inducers. PLoS Medicine; in press, 2006.
4. Hillary Crandall,* Ying Ma,* Diane M. Dunn, Rhianna S. Sundsbak,* James F. Zachary,Peter Olofsson,§ Rikard Holmdahl,§John H. Weis,* Robert B. Weiss,† Cory Teuscher,and Janis J. Weis*,Bb2Bb3 Regulation of Murine Lyme Arthritis Is Distinct from Ncf1 and Independent of the Phagocyte Nicotinamide Adenine Dinucleotide Phosphate Oxidase, American Journal of Pathology, Vol. 167, No. 3, September 2005
5. M Johannesson1,3, LM Olsson1,3, A-KB Lindqvist1, S Möller2, D Koczan2, L Wester-Rosenlöf1, H-J Thiesen2, S Ibrahim2 and R Holmdahl1 Gene expression profiling of arthritis using a QTL chip reveals a complex gene regulation of the Cia5 region in mice, Genes and Immunity (2005), 1-9 & 2005
6. Nandakumar Kutty Selva and R Holmdahl, A genetic contamination in MHC-congenic mouse strains reveals a locus on chromosome 10 that determines autoimmunity and arthritis susceptibility, Eur. J. Immunol. 2005. 35:
7. Harald Burkhardt,1 Ulrike Hüffmeier,1 Bernd Spriewald,1 Beate Böhm,1 Rolf Rau,2 Stefan Kallert,1 Åke Engström,3 Rikard Holmdahl,4 and Andre´ Reis, Association Between Protein Tyrosine Phosphatase 22 Variant R620W in Conjunction With the HLA-DRB1 Shared Epitope and Humoral Autoimmunity to an Immunodominant Epitope of Cartilage-Specific Type II Collagen in Early Rheumatoid Arthritis, ARTHRITIS & RHEUMATISM Vol. 54, No. 1, January 2006, pp 82-89
8. Maria Liljander1, Mary-Ann Sällström1, Sara Andersson1, Åsa Andersson2, Rikard Holmdahl3 and Ragnar Mattsson, Identification of collagen-induced arthritis loci in aged multiparous female mice, Arthritis Research & Therapy 2006, 8:R45 (doi:10.1186/ar1901)
9. Anna-Karin B. Lindqvist,2* Martina Johannesson,* Åsa C. M. Johansson,* Kutty S. Nandakumar,* Anna M. Blom,† and Rikard Holmdahl3, Backcross and Partial Advanced Intercross Analysis of Nonobese Diabetic Gene-Mediated Effects on Collagen-Induced Arthritis Reveals an Interactive Effect by Two Major Loci1, The Journal of Immunology, 2006, 177: 3952-3959.
3 Biomedical Sciences Research Center "Alexander Fleming", Athens
1. Alexopoulou L, Kranidioti K, Xanthoulea S, Denis M, Kotanidou A, Douni E, Blackshear PJ, Kontoyiannis DL, Kollias G 2006, "Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity.", Eur J Immunol., 2006 Oct, 36(10):2768-80
2. ictoratos P, Lagnel J, Tzima S, Alimzhanov MB, Rajewsky K, Pasparakis M, Kollias G, 2006, "FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses. ", Immunity., 2006 Jan, 24(1):65-77.
3. Argyropoulos C, Chatziioannou AA, Nikiforidis G, Moustakas A, Kollias G, Aidinis V., 2006, "Operational criteria for selecting a cDNA microarray data normalization algorithm.", Oncol rep., 2006, 15:983-996
4. Aidinis V, Carninci P, Armaka M, Witke W, Harokopos V, Pavelka N, Koczan D, Argyropoulos C, Thwin MM, Moller S, Kazunori W, Gopalakrishnakone P, Ricciardi-Castagnoli P, Thiesen HJ, Hayashizaki Y, Kollias G, 2005, "Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis", PLoS Genet., 2005 Oct, 1(4):e48
5. The FANTOM consortium, 2005, "The transcriptional landscape of the mammalian genome", Science 2005 Sep 2;309(5740), 1559-63
6. Kollias G., 2005, "TNF pathophysiology in murine models of chronic inflammation and autoimmunity", Semin Arthritis Rheum., 2005 Apr;34(5 Suppl1), 3-6. Review.
7. Kollias G., 2004, "Modeling the function of tumor necrosis factor in immune pathophysiology", Autoimmun. Rev., 3 Suppl 1, S24-5
8. Xanthoulea S., Pasparakis M., Kousteni S., Brakebusch C., Wallach D., Bauer J., Lassmann H., Kollias G., 2004, "Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases", J. Exp. Med., 2;200 (3), 367-76
9. Douni E., Sfikakis P. P., Haralambous S., Fernandes P., Kollias G., 2004, "Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti-TNF protocols", Arthritis Res. & Ther., 6 (1), R65-R72
10. Aidinis V., Plows D., Haralambous S., Armaka M., Papadopoulos P., Kanaki M. Z., Koczan D., Thiessen H. J., Kollias G., 2003, "Functional analysis of an arthritogenic synovial fibroblast", Arthritis Res. & Ther., 5, 140-157
11. Carninci P., Waki K., Shiraki, Konno H., Shibata K., Itoh M., Aizawa K., Arakawa T., Ishii Y., Sasaki Y., Bono H., Kondo S., Sugahara Y., Saito R., Osato N., Fukuda S., Sato K., Watahiki K., Hirozane-Kishikawa T., Nakamura M., Shibata Y., Yasunishi A., Kikuchi N., Yoshiki A., Kusakabe M., Gustincich S., Beisel K., Pavan W., Aidinis V., Nakagawara A., Held W., Iwata H., Kono T., Nakauchi H., Lyons P., Wells C., Hume D., Fagiolini M., Hensch T., Brinkmeier M., Camper S., Muramatsu M., Okazaki Y., Kawai Y., Hayashizaki Y., 2003, "Targeting a complex transcriptome: The construction of the mouse full-length cDNA encyclopedia", Genome Res., 13, 1273-89
4. German Arthritis Research Centre Berlin
1. Steinbrich-Zöllner M., Grün J., Häupl T., Pade S., Burmester G-R., Radbruch
A., Grützkau A. Gene expression profiling meets multicolor flow cytometry - an integrated approach to monitor candidate genes at the single cell level in chronic rheumatic diseases. Zeitschrift für Rheumatologie Band 65, Supplement 1, 2006
Publication with two network partners involved:
2. Mahr S, Burmester GR, Hilke D, Gobel U, Grutzkau A, Haupl T, Hauschild M, Koczan D, Krenn V, Neidel J, Perka C, Radbruch A, Thiesen HJ, Muller B.Cis- and trans-acting gene regulation is associated with osteoarthritis. Am J Hum Genet. 2006 May;78(5):793-803.
5 Kennedy Institute London
1. Wojciak-Stothard B, Tsang LY, Paleolog E, Hall SM, Haworth SG (2006) Rac1 and RhoA as regulators of endothelial phenotype and barrier function in hypoxia-induced neonatal pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 290, L1173-1182
2. Syeda F, Grosjean J, Houliston RA, Keogh RJ, Carter TD, Paleolog E, Wheeler-Jones CP (2006) Cyclooxygenase-2 Induction and Prostacyclin Release by Protease-activated Receptors in Endothelial Cells Require Cooperation between Mitogen-activated Protein Kinase and NF-{kappa}B Pathways. J Biol Chem 281, 11792-11804
3. Jain A, Kiriakidis S, Brennan F, Sandison A, Paleolog E, Nanchahal J (2006) Targeting Rheumatoid Tenosynovial Angiogenesis with Cytokine Inhibitors. Clin Orthop Relat Res 446, 268-277
4. Grosjean J, Kiriakidis S, Reilly K, Feldmann M, Paleolog E (2006) Vascular endothelial growth factor signalling in endothelial cell survival: A role for NFkappaB. Biochem Biophys Res Commun 340, 984-994
5. Sumariwalla P, Cao Y, Wu H, Feldmann M, Paleolog E (2003) The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis. Arthritis Res Ther 5, R32-R39
6. Kiriakidis S, Andreakos E, Monaco C, Foxwell B, Feldmann M, Paleolog E (2003) VEGF expression in human macrophages is NF-oB-dependent: studies using adenoviruses expressing the endogenous NF-oB inhibitor IoBo and a kinase defective form of the IoB kinase 2. Journal of Cell Science 116, 665-674
7. Andreakos E, Smith C, Kiriakidis S, Monaco C, De Martin R, Brennan FM, Paleolog E, Feldmann M, Foxwell B (2003) Heterogeneous requirement of IoB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy. Arthritis and Rheumatism 48, 1901-1912
8. Afuwape A, Feldmann M, Paleolog E (2003) Adenoviral delivery of soluble VEGF receptor 1 (sFlt-1) abrogates disease activity in murine collagen-induced arthritis. Gene Therapy 10, 1950-1960
9. Paleolog, E.M., Young, S., Stark, A.C., McCloskey, R.V., Feldmann, M. and Maini, R.N. (1998) Modulation of angiogenic vascular endothelial growth factor (VEGF) by TNFalfa and IL-1 in rheumatoid arthritis. Arthritis & Rheumatism 41: 1258-1265.
10. Synovial fibroblasts are important mediators of synovial angiogenesis in the hypoxic rheumatoid joint Vascular Pharmacology, Volume 45, Issue 3, September 2006, Page e118 Helene Larsen, Marc Feldmann and Ewa Paleolog
11. Expression profiling of angiogenic markers in murine CIA models Vascular Pharmacology, Volume 45, Issue 3, September 2006, Page e13 Yvonne Raatz, David Essex, Saleh Ibrahim and Ewa Paleolog
6. VU University Medical Center, Amsterdam
1. Van der PouwKraan TC, Van Gaalen FA, Huizinga TWJ, Pieterman E, Breedeveld FC and Verweij CL. Genes Immun. 2003 Apr;4(3):187-96.
2. Van der PouwKraan TC, Van Gaalen FA, Kasperkovitz PV, Verbeet NL, Smeets TJ, Kraan MC, Fero M, Tak PP, Huizinga TWJ, Pieterman E, Breedveld FC, Verweij CL. Arthritis Rheum. 2003 Aug;48(8):2132-45.
3. van Rietschoten JG, Verzijlbergen KF, Gringhuis SI, Kraan TC, Bayley JP, Wierenga EA, Jones PA, Kooter JM, Verweij CL. Differentially methylated alleles in a distinct region of the human interleukin-1alpha promoter are associated with allele-specific expression of IL-1alpha in CD4+ T cells. Blood. 2006 Oct 1;108(7):2143-9
4. Pia V. Kasperkovitz 1, Trieneke C. G. Timmer 1, Tom J. Smeets 2, Nicolette L. Verbeet 1, Paul P. Tak 2, Lisa G. M. van baarsen 1, Belinda Baltus 1, Tom W. J. Huizinga 3, Elsbet Pieterman 3, Mike Fero 4, Gary S. Firestein 5, Tineke C. T. M. van der Pouw Kraan 1, Cornelis L. Verweij. Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: Evidence of a link between an increased myofibroblast-like phenotype and high-inflammation synovitis. Arthritis Rheum. 2005 Feb;52(2):430-41.
5. T.C.T.M. van der Pouw Kraan, C.A. Wijbrandts, L.G. van Baarsen, A.E. Voskuyl, F. Rustenburg, J.M. Baggen, S.M. Ibrahim, M.Fero, B.A.C. Dijkmans, P.P. Tak, and C.L. Verweij. Rheumatoid Arthritis subtypes identified by genomic profiling of peripheral blood cells: Assignment of a type I interferon signature in a subpopulation of patients. Ann. Rheum. Dis. In press.
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